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#2965 Molecular Signature of Rectal Neuroendocrine Neoplasia
Introduction: Rectal neuroendocrine tumors are rare neuroendocrine neoplasias (NEN). Little is known about prevalence and type of somatostatin receptor subtypes (sstr) expression and somatic mutations in relation to long-term clinical outcome.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Unger N, Theurer S, Herold T, Weber F, Dralle H,
Keywords: Somatic Mutations, NGS, Somatostatin receptor subtypes, Intestinal NEN,
Introduction: Estimating prognosis of pancreatic neuroendocrine tumor (PNET) patients remains challenging. Mutation status of DAXX/ATRX/MEN1, histone modification patterns and immunohistochemistry for relevant transcription factors, including PDX1, were recently used to perform subtyping and distinguished two main types, A and B. These subtypes are linked to cell-of-origin and associated with clinical outcome.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Boons G, Vandamme T, Ibrahim J, Schepers A, Roeyen G,
Keywords: Pancreatic Neuroendocrine Tumor, DNA Methylation, Prognostic Biomarker,
Introduction: Bone metastases have been described in up to 32% of NET patients and are associated with a worse clinical outcome. Overexpression of CXCR4 in primary tumors appears predictive of skeletal involvement.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author:
Introduction: Neuroendocrine neoplasms of unknown primary (NENs-UP) account for 10-13% of all NENs and show different biologic behavior, histologic appearance and clinical outcome.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Zilli A
Authors: Massironi S, Fanetti I, Cavalcoli F, Zilli A, Conte D,
Keywords: Neuroendocrine tumors, unknown primary,
Introduction: Chemokine receptor CXCR4 has been shown to signal on mTOR pathway in gastric and renal cancer. CXCR4 interacts with the chemokine CXCL12 to exert proliferative and chemotactic effects.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Sciammarella C
Authors: Sciammarella C, Circelli L, Guadagno E, Tafuto S, Del Basso De Caro M,
Keywords: chemokine, mtor, nets, clinical outcome.,